Health Sciences Investigations (HSI) Journal 2021-09-20T03:46:40+02:00 The Managing Editor Open Journal Systems <p><a href=""><em>click here</em></a> to homepage</p> <p><strong>Welcome to the Health Sciences Investigations (HSI) Journal</strong></p> <p><strong>Our aim</strong></p> <ul> <li class="show">The HSI Journal is an independent, international journal intended for the publication of original articles from the global scientific community. To reach the global community, especially those in resource-limited regions, HSI Journal provides on-line Open Access publications at no cost to authors and readers.</li> </ul> <p><strong>Our Mission</strong></p> <ul> <li class="show">The HSI journal is a peer-reviewed journal for the communication of research results and policy issues in the health sciences and related disciplines. Our mission is to increase the visibility and impact of health sciences research in Ghana and globally</li> </ul> <p><strong>&nbsp;</strong><strong>Licensing</strong></p> <ul> <li class="show">ID: Health Sciences Investigations (HSI) Journal</li> <li class="show">Electronic ISSN: 2704-4890 (ONLINE)</li> <li class="show">Print ISSN: 2720-7609 (PRINT)</li> <li class="show">Language: English</li> <li class="show">Webspace: <a href=""></a></li> </ul> <p><strong>&nbsp;</strong><strong>Scope</strong></p> <ul> <li class="show">Health Sciences Investigations (HSI) Journal publishes manuscripts from basic and clinical health sciences including medicine, biomedicine, pharmacy, nursing, physical therapy, medical laboratory science, environmental health, public health, medical imaging and radiologic technologies and other allied health disciplines. The Journal is dedicated to serving scientists wishing to contribute to knowledge on global health. All HSI Journal publications are in English.</li> <li class="show">The Journal publishes original research articles, systematic reviews, case reports, brief communications and letters to the editor. The journal also publishes interviews with global opinion leaders and policy makers on health matters of global relevance. We welcome original contributions that have not been published and are not under consideration for publication elsewhere. Papers accepted for publication are double-blind refereed to ensure academic integrity.&nbsp;</li> </ul> <p><strong>Publication model</strong></p> <ul> <li class="show">The HSI Journal's complete issues and individual articles are all open access.</li> <li class="show">All content in HSI can be freely accessed here at the journal's official website and also at other subscribed article indexing and archiving platforms. The list of indexed and/or archiving platforms will be continually be updated and displayed on the Journal website.</li> </ul> <p><strong>Frequency of publication</strong></p> <ul> <li class="show">Online first publications.&nbsp;We provide online first publications (E-Publication First<sup>TM</sup>). All accepted papers are published online soon after completion of the necessary publishing processes. The HSI Journal hosts online PDF and HTML versions of manuscripts that have been peer-reviewed and accepted so that readers can freely access or cite the articles.</li> <li class="show">All published articles are subsequently compiled in final printed editions that are produced in two volumes during the reference year.</li> </ul> <p><strong>The HSI Journal Office</strong></p> <ul> <li class="show">The HSI Journal ais located at the University of Ghana College of Health Sciences, Charles Easmon Building, 2<sup>nd</sup> floor, Room 21, Korle-Bu, Accra, Ghana. The Journal’s administrative office maintains all subscription records.</li> </ul> <p><strong>The HSI Journal address</strong></p> <ul> <li class="show">Office address:&nbsp; University of Ghana College of Health Sciences, Charles Easmon Building, 2<sup>nd</sup> floor, Room 21, P.O Box K52, Korle-Bu, Accra, Ghana.</li> </ul> <ul> <li class="show">Contact email: <a href=""></a> / <span style="text-decoration: underline;"></span></li> </ul> <ul> <li class="show">Contact numbers:</li> </ul> <p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Mrs Yvonne Okantey:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;+233 244156175</p> <p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Prof. Regina Appiah-Opong:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;+233 249052475</p> <p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Prof. Christabel Enweronu-Laryea: &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;+233 208154886</p> <ul> <li class="show">To advertise, reproduce the content in the HSI Journal, or request for printed HSI Journal editions, please send an email to <a href=""></a> or call</li> </ul> <p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Mrs Yvonne Okantey: &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;+233 244156175</p> <p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Mr Godfred Amoah: &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;+233 244110902</p> <p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Mr Daniel Abankwa:&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;+233 024953 4022</p> <p><strong>Article processing charges&nbsp;</strong></p> <ul> <li class="show">There are no associated publication charges. We invite you to submit manuscripts via the <a href="">online submission platform</a>. There are no charges to publication in HSI Journal. Solicited reviews, commentaries, and comment letters to the Editor-in-Chief are not subject to print-page charges. New data letters to the Editor-in-Chief are not subject to print-page charges. Authors whose research were supported by grants, special funds or contracts or whose research were done as part of their official duties (government or corporate, etc.) are also not required to pay page charges.</li> </ul> <p><strong>Copyright statement</strong></p> <p>The HSI Journal conforms to the Creative Commons Attribution BY &nbsp;license. This copyright license permits others to distribute, remix, tweak, and build upon your work, even commercially, as long as they credit us for the original creation. More information on copyright and licensing information can be found <a title="creaticecommons" href=""><em></em></a></p> <p><strong>Copyright ownership</strong></p> <ul> <li class="show">All content in the HSI Journal is published by the University of Ghana College of Health Sciences. All rights reserved. The HSI Journal publishes articles in Open Access at no cost to authors to allow for the widest visibility of the article. Upon acceptance of the article, authors will be asked to transfer copyright of the article to the HSI Journal. This will ensure the widest possible protection and dissemination of information under copyright laws.</li> <li class="show">The copyright transfer covers the exclusive right to reproduce and distribute articles in the HSI Journal, including reprints, translations, photographic reproductions, microform, electronic form (offline, online) or any other reproductions of similar nature. All rights reserved. No part of publications in HSI Journal may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the written permission of the copyright holder. Authors retain all proprietary rights such as patent rights, in any process, procedure or article of manufacture described in the paper. The HSI Journal is Open Access with no publication charges. The copyright to each article is transferred to the University of Ghana College of Health Sciences on behalf of the HSI Journal. when their manuscript is accepted for publication.</li> </ul> <p><strong>Publication Ethics</strong></p> <ul> <li class="show">The HSI Journal is committed to supporting standards of ethical behaviour at all stages of the publication process. The HSI Journal adopts a neutral position on issues treated within its publications. It is the responsibility of authors to ensure that they comply with HSI Journal publication standards and guidelines. Our publication ethics conform to the <u>Committee on Publication Ethics (COPE)</u> Best Practice Guidelines. The COPE standards protect the rights of authors, editors, reviewers and publishers alike, and seeks to uphold the reputation of journals and . The Journal adheres to publication standards of the International Committee of Medical Journal Editors (ICMJE; <a href=""></a>), Committee on Publication Ethics (COPE; <a href=""></a>), and the World Association of Medical Editors (WAME; <a href=""></a>).</li> <li class="show"><img src="/ojs/public/site/images/admin/cope3.gif" width="216" height="80"></li> </ul> <p><strong>Review Policy</strong></p> <ul> <li class="show">The HSI Journal follows double blind peer review policy. The manuscript is sent to two reviewers, who are experts in respective field, to review the paper in the light of journal's guidelines and features of a quality research paper. For manuscript that require revisions, the same reviewers will be used to ensure that the quality of the revised paper is acceptable.</li> <li class="show">We operate a transparent peer review process for the HSI Journal where reviewers’ names do not accompany reviewer comments to authors (unless a reviewer opts to include the name), which means that authors by default will not see the reviewers' names but only their comments. By agreeing to provide a report, reviewers understand that their reports will be made available, upon request, under an Open Access license Creative Commons CC-BY license (<a href="" data-auth="NotApplicable"></a>) if the manuscript is published.</li> </ul> <p><strong>Disclaimer</strong></p> <ul> <li class="show">Opinions and statements expressed in the publications are those of the authors alone, and not of the editors, reviewers or the HSI Journal and its publisher.</li> </ul> <p><strong>Privacy Statement</strong></p> <ul> <li class="show">The names, email addresses, and information entered in this journal site will be used exclusively for the stated purposes of this journal and will not be made available for any other purpose or to any other party.</li> </ul> <p><strong>Research suitable for publication</strong></p> <ul> <li class="show">Please consult the Editorial Policies of the HSI Journal before preparing a manuscript for publication. Manuscripts that are inconsistent with the guidelines shall be declined by the Editor-in-chief without subjecting it to the full review. The HSI author guidelines conform to the ICMJE uniform requirements of manuscripts at <a href=""><u>http:/</u></a></li> </ul> <p>&nbsp;</p> Welcome message from the Editor-in-chief 2021-09-20T03:42:52+02:00 Andrew Anthony Adjei <p>Improvement, achievement, and success have no meaning without continual growth and progress. I write this editorial to welcome authors, reviewers, and readers to the third edition of the HSI Journal Volume 2 Issue 1 in 2021. It is my pleasure to announce that all 3 issues of the HSI Journal were published online on time and the print issues were also brought out and dispatched within a month of publishing the issue online. Towards this edition, the HSI Journal received several manuscripts - some were rejected in the preliminary screening and others after peer review process. A total of 43 research scientists from different juridictions reviewed the manuscripts submitted to this edition. Some of the accepted articles are presented in this issue. Altogether, there are 6 original research articles, 4 case reports, and a commentary. The average publication lag time for publication of an article was 2-3 months. The topics covered are broad but interesting and scientifically relevant. The HSI Journal is an Open Access publication with no article processing charges, and all published articles are accessible for greater dissemination. The Journal subscribes to the progressive thinking that access to scientific knowledge must benefit all without recourse to purchasing power. I take this opportunity to acknowledge the contributions of editorial board members and reviewers covering all related topics, especially during the final editing of the published articles. I would also like to express my gratitude to the publisher, all the authors, the advisory board, and office bearers for their support in bringing out yet another volume of the HSI Journal. I am indeed blessed with an excellent team. I look forward to their unrelenting support to bring out Volume 2 Issue 2 at the scheduled time. As the Editor-in-chief, I welcome suggestions, complaints, discussions, and thoughts from authors and readers to help us to maintain high standards. We look forward to publishing high-quality studies and making the HSI Journal synonymous with top quality in health sciences research. Acknowledgements, The University of Ghana College of Health Sciences, the copyright owner, the patron, and sponsor of HSI Journal has always shown a deep interest in the affairs of its constituent institutions. The Journal is indeed grateful to the Reverend Professor Patrick Ferdinand Ayeh-Kumi, the Provost of the University of Ghana College of Health Sciences, for his immense support and leadership.</p> 2021-06-29T00:00:00+02:00 Copyright (c) 2021 University of Ghana College of Health Sciences About the cover 2021-09-20T03:42:29+02:00 Crentsil Tabi <p>“Dawuro”.<br>A town crier beating the dawuro<br>Artist’s perspective<br>The dawuro is one of the traditional Ghanaian methods of drawing attention to the town crier, before an important message is delivered to the townsfolk. It is a locally fabricated bell-like steel instrument with two hollow heads. In the painting the dawuro beater is faceless, rather, the dawuro is identifiable, which suggests the importance and prominence of the act, rather than the actor. The painting also has an almost graphic description of the hands of the actor. This suggests that the act of communication must be in good and decisive hands. The monument, as captured in the painting, suggests a steadfast community's unflinching desire to be served with consistent communication. Monuments capture the soul of a people and enshrines their values. “Dawuro”<br>A town crier beating the dawuro. The dawuro is a double metal bell idiophone used in Ghana. The instrument is played with a hard wooden stick or a metal rod, which is used to strike the bell. This produces a clear sound with a long echo. Editors’ view<br>Amidst abundance, there is the possibility of starvation. In today’s world of information glut, discerning consumers have increasingly become skeptical of the information they receive. They are concerned about the accuracy of the information and the legitimacy of the source. Like the prominent hands beating the dawuro to disseminate knowledge, the HSI Journal is committed to sharing research findings. We strive issue after issue, to serve the community of hungry minds with consistent supply of relevant scientifically accurate information for the advancement of humanity. And, this is most imperative in the season where the COVID-19 pandemic has ravaged many economies and lives with no end in sight. While we pay tributes to all who have fallen as victims, we encourage all and sundry not to give up, but to stand strong with us to tell our stories the best ways we can since sharing is caring. Let us stand strong without cowardice and actively participate in the story-sharing process by which we may obtain relief, commonness, and advancement.<br>How to cite<br>Crentstil T (2021) About the cover “Dawuro”. Health Sciences Investigations Journal 2 (1): . Email: WhatsApp: +233 245390591</p> 2021-06-29T00:00:00+02:00 Copyright (c) 2021 University of Ghana College of Health Sciences Commentary on a case report of Dopa-responsive dystonia or Segawa disease in Ghana 2021-09-20T03:42:06+02:00 Kwame Mathew Yamoah Kyei <p>The case of Dopa-Responsive Dystonia or Segawa Disease reported in this issue brings to the fore the age-old tenets of medicine which is based on the taking of a detailed history, physical examination, and the request of relevant investigations to achieve a diagnosis. This is followed with an evidence-based treatment planning. This maxim remains important especially in resource poor environments where sometimes one must depend on the history and physical examination findings alone to make a diagnosis and commence treatment. The patient under review had had her condition progressively worsening for two years and had been managed as a case of cerebral palsy.<br>The initial consideration of a possible dyskinetic cerebral palsy from bilirubin encephalopathy which the author indicated was common is understandable as this is one of the commonest causes of such presentation in the setting. However, having a more detailed history and having other differentials in mind such as childhood Dopa-Responsive Dystonia, as was the case presented, helped in identifying subtle differences in presentation that influenced the ultimate diagnosis. In this case, a later onset of symptoms (dystonia), with the symptoms being minimal after sleep and becoming more severe late afternoon having helped to clinch the diagnosis. Considering each patient one sees as eligible for a possible case report allows one to update his or her knowledge on the condition, identify peculiar features and directs the request of relevant investigations. The use of telemedicine is yet to be widespread in the developing world even though telecommunication infrastructure is improving in these regions. This case had the diagnosis essentially made by contacting a paediatric neurologist by telephone. Such specialist consultations need to be encouraged as there are very few specialists across the globe and less still in the developing economies.<br>Governments and Medical Associations may have to lead in creating these platforms to assist in this direction to improve the overall access to specialist care and reviews in less endowed regions. In the case presented, the diagnosis of Dopa-Responsive Dystonia was confirmed after a demonstration of a marked and sustained response to low dose L-dopa without motor fluctuations or dyskinesias. We applaud the author for the diagnosis having been made by essentially a detailed history and physical examination and response to L-dopa. It was however indicated that there are recent developments that involve analysis of cerebrospinal fluid for neurotransmitters that demonstrate low concentrations of biopterin and neopterin with DNA sequencing demonstrating mutation of the GTP cyclohydrolase-1 gene in up to 80% of cases in gene studies. These diagnostic tests hinge on the finding of an autosomal dominant heterozygous mutation in the GTPcyclohydrolase-I gene that results in biopterin deficiency, a cofactor for tyrosine hydroxylase and dopamine deficiency and considered the most classic molecular pathophysiology of this condition [1]. These additional tests were not done bringing to the fore the limited access to investigative tools in some developing economies. While National Reference Laboratories are in existence in some countries, regional efforts could be made to set up reference laboratories that serve entire region to allow for pooling of infrequently performed laboratory tests for analysis. This will make such infrequently encountered medical conditions be accurately diagnosed and treated. Of concern is how to achieve an un-interrupted supply of L-Dopa as the child returns to the village. This should engage the attention of all involved in her treatment as they follow the patient up.<br>To conclude, the suggestion by the author that the diagnosis of Dopa-Responsive Dystopia or Segawa disease must be considered in all cases of dystonia including cases of apparent dystonic cerebral palsy and especially where there is no history of birth asphyxia need being emphasized.<br><br></p> 2021-06-29T00:00:00+02:00 Copyright (c) 2021 University of Ghana College of Health Sciences Intractable bleeding; the role of embolization in a resource-limited country 2021-09-20T03:46:40+02:00 Benjamin D. Sarkodie Bashiru Jimah Dorothea Anim <p>Transarterial catheter embolization is novel in Ghana, even though it has been practiced over three decades certain parts of the world. The procedure is safer with the advent of new catheter techniques and embolic agents and thus placed interventional radiology at the forefront of the treatment of bleeding due to myriad of indications. It is fast, safe and minimally invasive relative to open surgery especially when other conventional minimally invasive procedures such as endoscopic banding and sclerotherapy fails. This paper presents two cases who underwent pre- and post-embolization digital subtraction angiogram (DSA) &nbsp;of gastroduodenal artery and bilateral iliac arteries respectively. Findings of pre-embolization digital subtraction angiogram (DSA) of the gastroduodenal artery and bilateral iliac arteries shows florid extravasation and extensive neovascularity. Post embolization DSA shows absent extravasation and near total devascularization. Recommend inclusion of embolization to the management protocols of upper gastrointestinal bleeding and intractable hematuria.</p> 2021-06-29T00:00:00+02:00 Copyright (c) 2021 University of Ghana College of Health Sciences on behalf of the HSI Journal Uretero-vesical anastomotic stricture. A case report and review of management 2021-09-20T03:44:46+02:00 Mathew Yamoah Kyei Robert Djagbletey George Oko Klufio James Edward Mensah Bernard Toboh <p>Uretero-vesical anastomosis is the connection of the ureter to the urinary bladder at a new site so as to achieve unimpeded flow of urine from the ureters into the urinary bladder. A rare complication of this procedure is the development of stricture at the anastomotic site.</p> <p>This report is on a 62 year old female with one year history of left flank pain and a prior left uretero-vesical anastomosis 14 years earlier. She had been managed as recurrent urinary tract infection without pain relief. Abdomen pelvic CT Scan with intravenous urogram helped establish the diagnosis of uretero-vesical anastomotic stricture. This was successfully managed with endoscopic dilatation after placement of a guide wire retrogradely under fluoroscopy followed by serial dilation.</p> <p>In a patient presenting with flank pains after a previous uretero-vesical anastomosis, stricture at the anastomotic site is an important differential diagnosis. Endoscopic management is the preferred initial management with good success.</p> 2021-06-29T00:00:00+02:00 Copyright (c) 2021 University of Ghana College of Health Sciences on behalf of the HSI Journal